Göran Skog
Universitetslektor
Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating
Författare
Summary, in English
Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.
Avdelning/ar
- Kardiovaskulär forskning - translationella studier
- EXODIAB: Excellence of Diabetes Research in Sweden
- Kärnfysik
- Vaskulära sjukdomar - kliniska studier
- Kvartärgeologi
- Medicinsk strålningsfysik, Malmö
- Kardiovaskulär forskning - immunitet och ateroskleros
- EpiHealth: Epidemiology for Health
Publiceringsår
2021
Språk
Engelska
Sidor
734-745
Publikation/Tidskrift/Serie
JACC: Basic to Translational Science
Volym
6
Issue
9-10
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cardiac and Cardiovascular Systems
Status
Published
Forskningsgrupp
- Cardiovascular Research - Translational Studies
- Vascular Diseases - Clinical Research
- Medical Radiation Physics, Malmö
- Cardiovascular Research - Immunity and Atherosclerosis
ISBN/ISSN/Övrigt
- ISSN: 2452-302X